Deniz Cizmeciyan-Papazyan - PhD
Professor, Physical Sciences
Post-Doctoral Scholar, 1996 - 1998, Chemical Engineering, California Institute of Technology
Post-Doctoral Scholar, 1994 - 1996, Chemistry and Biochemistry, UCLA
PhD, Chemistry, 1994, The Pennsylvania State University
BS, Chemistry, 1987, Bogazici University (Istanbul, Turkey)
The main focus of my research has been experimental until recently. In collaboration with Dr. Miguel Garcia-Garibay’s group at UCLA, I investigated methyl group dynamics in relation with tunneling mechanism in photochemical reactions, photochemical reactions in zeolites as well as enantiomeric interactions in zeolites by means of Nuclear Magnetic Resonance (NMR), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC) and Gas Chromatography, Mass Spectrometry (GC-MS). However, in the past year my research interests have shifted to computational chemistry which has been growing in importance in the past decades, as acknowledged by Nobel prizes awarded in 1998 and 2013. Computational Chemistry, which was the focus of last spring’s American Chemical Society (ACS) meeting, is a powerful tool which provides a microscope into the behavior of molecules and materials at atomic level and is becoming an extremely powerful tool for gaining insight into chemical processes otherwise difficult or impossible to obtain from experiments. It can also be conducive to valuable interdisciplinary collaborations with mathematics and biology professors and students. For example, computational projects provide research opportunities for mathematics students as well as students in physical and life sciences.
One of my research projects is on investigating how amino acids get adsorbed into zeolites using MD and Monte Carlo Simulations. This project is in collaboration with Dr. Arno Papazyan. The goal of this project is to complement my experimental results in finding a new avenue to enantiomeric enrichment in an achiral medium provided by zeolites which are aluminosilicate cages with adsorption capabilities. The separation of one enantiomer from the other is a very important practical issue in medicine today because the incorrect enantiomer is either useless or may cause detrimental side effects. It also lies at the origin of life, since most of biochemistry involves chiral molecules. Our research efforts are towards making a significant and fundamental contribution to our knowledge about the repertoire of processes leading to enantiomeric purity.
My other research project focuses on the theory of Nuclear Magnetic Resonance (NMR). This project is in collaboration with Joshua Helston and Dr. Alan Benesi. The goal for the mathematics and mathematically inclined chemistry and biochemistry students is to learn the mathematics underlying Nuclear Magnetic Resonance (NMR), which is a very important and useful technique in science and medicine, forming the basis of several Nobel Prize winning discoveries, with Nobel prizes awarded in 1946, 1991, 2002, 2003, and inventions, including the life-saving Magnetic Resonance Imaging (MRI) technology. NMR can probe into the nuclei of atoms and inform us about molecular structures and environments, motions, proximities of atoms, and rates of reactions. Using algorithms in Dr. Alan Benesi’s new book “A Primer in NMR Theory with Calculations in Mathematica” we are simulating the rotation rates of deuterium nuclei for water in gypsum at various temperatures. We have been able to investigate the molecular motion of D2O in gypsum, which has fire-retardant properties due to the water molecules in its crystals. Understanding molecular motion is crucial for reactions and properties of molecules.
My research group includes chemistry, mathematics, biochemistry and biology students. We showcase our work in several scientific conferences at Mount Saint Mary’s University and elsewhere such as the American Chemical Society (ACS) Meetings, The Experimental NMR Conference (ENC), The Southern CA Conference of Undergraduate Research (SCCUR), and the Southern CA Users of Magnet (SCUM) meetings. My research students have been accepted to Ph.D, PharmD, DPT Programs at prestigious universities such as John’s Hopkins, Texas A&M, UCLA, and University of Madison Wisconsin, UCLA, UCR, USC, Touro University and KGI of Claremont etc.
I am very active in the NMR community throughout Southern CA. I am the founder of the Los Angeles Area Magnetic Experts (LAME), which expanded to Southern CA becoming, the Southern CA Users of Magnets (SCUM) Meetings.
I am also invested in women’s success in the STEM fields as I was invited to act as moderator at the Berkshire Conference in June 2017, for a session entitled “STEM Education in Japan: Examining the Professionalization Pipeline for Females”. This roundtable session included prestigious scholars on the subject, such as Dr. Yuko Takahashi, President of the first Women University in Japan, Tsuda University, Dr. Yuko Itatsu, from The University of Tokyo and Dr. Diane Rodriguez-Kiino, from California Lutheran University.
Amboya, A., Nguyen, T., Huynh H., Brown, A., Ratliff, G.K., Yonutas, H.M., Cizmeciyan D.*, Natarajan, A., and Garcia Garibay, M. A*;“ Radical Pairs with Rotational Fluidity in the Photochemical Reaction of Acetophenone and Cyclohexane in the Zeolite NaY: A 13C CPMAS NMR and Product Analysis Study”, Organic & Biomolecular Chemistry, 7, 2322, 2009
Cizmeciyan, D., Yonutas, H.M., Karlen, S.D., and Garcia-Garibay, M.A.; “2H NMR and X-ray diffraction studies of methyl rotation in crystals of ortho-methyldibenzocycloalkanones”, Solid State Nuclear Magnetic Resonance, 28, 1, 2005
Cizmeciyan,D.; “Teaching About Numbers”, in Teaching Tips: Innovations in Undergraduate Science Instruction. NSTA Press, p.65, 2004
Cizmeciyan,D., Bartlett, C.; “The Value of a Poker Face and Other Lessons: Reflections on a year-long examination of student work in an introductory Physical Science course”, The National Teaching and Learning Forum. 12, 7, 2003
Saxena, S., Cizmeciyan, D. and Kornfield, J. A.; “Solid state 2H-NMR studies of segmental dynamics in polymer blends”, Solid State Nuclear Magnetic Resonance 12, 165, 1998
Shin, S. H., Cizmeciyan, D., Keating, A. E., Khan, S. I. and Garcia-Garibay, M. A.; “Control of Carbene Reactivity by Crystals. A Highly Selective 1,2-H Shift in the Solid to Solid Reaction of 1-(4’-Biphenylyl)-2-phenyldiazopropane to (Z)-1-(4’-Biphenylyl)-2-phenylpropene”, J. Am. Chem. Soc. 119, 1859, 1997
Cizmeciyan, D., Sonnichen, L. B. and Garcia-Garibay, M. A.; “Proximity Photochemical Reactivity and Intermolecular 1H-13C Cross Polarization of Benzophenone d10 and Cyclohexane in Zeolite NaX”, J. Am. Chem. Soc. 119, 184, 1997
Garcia-Garibay, M. A., Constable, A. E., Jernelius, J., Choi, T., Cizmeciyan, D. and Shin, S. H.; “Diffraction, Spectral and Thermal Analysis of Mixed Crystalline Phases”, Physical Supramolecular Chemistry, NATO ASI Series, Echegoyen, L. and Kaifer, A., Eds., 1996
Jackman, L. M. and Cizmeciyan, D.; “7Li Quadrupole Splitting Constants for Dimeric Lithium Phenolates in Weakly Polar Aprotic Solvents”, Magnetic Resonance in Chemistry 34, 14, 1996
Choi, T., Cizmeciyan, D., Khan, S. I and Garcia-Garibay, M. A.; “An Efficient Solid-to-Solid Reaction via a Steady-State Phase-Separation Mechanism”, J. Am. Chem. Soc. 117, 12893, 1995
Jackman, L.M., Cizmeciyan, D., Williard, P. G. and Nichols, M. A.; “Hexameric Lithium Phenolate. Crystal Structures and 7Li Quadrupole Coupling in Solid and Solution Phases”, J. Am. Chem. Soc. 115, 6262, 1993
Benesi, A. J., Jackman, L. M. and Cizmeciyan, D.; “Powder Lineshape Spin Gymnastics for I=3/2”, Texas A&M University NMR Newsletter 392, 19, 1991
Selected Scientific Presentations:
Moderator of “STEM Education in Japan: Examining the professionalization pipeline for females” at the Berkshire Conference, NY, June 2017
Speaker at The Southern California Users of Magnets, Cizmeciyan, D . “Solid State NMR research projects with Undergraduates”.March 5, 2016, University of California, Los Angeles, CA
Speaker at the Academic Conference, April 2016, Mount Saint Mary’s University, Cizmeciyan, D. “From the benches of Chemistry labs to interdisciplinary computational research: Fun with Mathematica and molecular simulations”
Speaker at The Southern California Users of Magnets, June 22, 2008, University of California, Irvine, CA Cizmeciyan,D.; “Photochemical reaction of Acetophenone and Cyclohexane in Zeolite Y studied by Solid State NMR”,
Seminar on Nuclear Magnetic Resonance in Organic Chemistry, May, 2008, LA Trade Technical College
Posters at the 235th National American Chemical Society Meeting, April 5-10, 2008, New Orleans, LA, Cizmeciyan,D.et. al.; “Photochemical reaction of Acetophenone and Cyclohexane in Zeolite Y studied by Solid State NMR”
Poster at the 49th Experimental NMR Conference (ENC), March 9-14, 2008, Asilomar, CA, Cizmeciyan,D.; et. al. “Photochemical reaction of Acetophenone and Cyclohexane in Zeolite Y studied by Solid State NMR”
Seminar on Nuclear Magnetic Resonance in Organic Chemistry, October, 2006, LA Trade Technical College.
Speaker at the National Science Teacher association Meeting, April 7, 2006, Anaheim, CA, Cizmeciyan, D. “The G.R.A.S.P.S. Assessment Task and Rubric for an Introductory Science Class”.
Speaker at the National Science Teacher association Meeting, April 7, 2006, Anaheim, CA, Cizmeciyan, D. “Choosing the Right G.R.A.S.P.S. Performance Task for the Right Class”.
Seminar on Nuclear Magnetic Resonance in Organic Chemistry, March 2, 2006, LA Trade Technical College
Speaker at The Southern California Users of Magnets, February 26, 2006, University of California, Irvine, CA, Cizmeciyan, D. “Fast Rotations of Methyl Groups in crystals of ortho-methyldibenzocycloalkanones”.
Seminar on Nuclear Magnetic Resonance in Organic Chemistry, September and April, 2005, LA Trade Technical College.
Speaker at The 229 National American Chemical Society Meeting, March 13-18, 2005, San Diego, CA, Cizmeciyan, “Fast Rotations of Methyl Groups in crystals of ortho-methyldibenzocycloalkanones”.